The 2013 Midwest Regional Championship was a competition between New Directions, The Hoosierdaddies and The Waffletoots. The theme is Dreams. New Directions got first place, the Hoosierdaddies place second and the Waffletoots place third. The Nun-Touchables were originally meant to be competing, but due to a scandal, the pope excommunicated them. They were then replaced by The Waffletoots.
- The Regionals ended Season Four. This is the second time that a Regional competition ends a season, 2010 Midwest Regional Championship from Season One being the first.
- The lead singer of The Hoosierdaddies is Frida Romero, portrayed by the runner-up of the 11th season of American Idol, Jessica Sanchez.
- In All or Nothing, it was revealed that the Nun-Touchables were excluded from the competition due to the new Pope excommunicating them because of a sexting scandal and replaced by the one of the top 10 show choirs at 2011 National Show Choir Championship, the Waffletoots.
- The venue of the competition was changed from Indianapolis (The Hoosierdaddies city) to The April Rhodes Civic Pavilion because of the bad weather and the hurricanes that occurred there recently. It was also because New Directions were the defending regional champions.