They meet for the first time this episode. They both go to The Rachel Berry House Party Train Wreck Extravaganza, along with the rest of the New Directions. While watching Blaine's performance of Don't You Want Me with Rachel, Santana shouts "I want you, I do," possibly towards Blaine.
When Dave starts making homophobic comments towards Blaine and Kurt in the hallway, Santana shows up and threatens him with physical violence: "I have razor blades hidden in my hair." Intimidated and bewildered, Dave leaves. Blaine then says to Santana, with a slight smile "We could've handled that." She replies with a smile and says "It was more fun doing it together." Santana receives a tweet on her phone and leaves Blaine, looking on amused.
Kurt, Blaine, Santana, Mercedes, and Tina are seen discussing Nationals at the Lima Bean. Santana wanders off in her thoughts of becoming Prom Queen, and while leaving she mistakenly says "I've got to gay," soon correcting herself with "I've got to go." She walks off, and Blaine is seen grinning at what she said.It's Not Unusual in the McKinley courtyard, Santana turns around from her table, smiles and makes a hand gesture towards the Cheerios to start dancing with Blaine. She soon gets up with the rest of the Cheerios and starts dancing with Blaine. They both smile at each other, but Santana's smile seems more devious than Blaine's. Without Blaine's knowledge, Santana has the Cheerios pour lighter fluid on the piano causing it to go up in flames when Quinn flicks a lit cigarette onto it, leaving Blaine confused and shocked. Later, in the choir room, she corrects Finn on who started the fire when he attacked Blaine for it.
During Blaine's performance of Last Friday Night, Santana gives Blaine dirty and weird looks. She also refuses to participate in it, even though everyone else seems to be dancing and having fun. Afterwards, Santana is annoyed because she claims New Directions is going to become the "Rachel and Blaine show" now that Mercedes is gone. Santana is also the only member of the New Directions who does not participate in the musical number.
Blaine and Kurt try and console Santana about her recent outing by singing Perfect to her. She makes a comment to Blaine about his sense of fashion, telling him to lay off the bow ties. Santana then tells them that she will add the song to the list of crap she has been through in her life.
Santana and Blaine are seen discussing Michael Jackson at the Lima Bean, and later seen together in a parking garage during the confrontation with The Warblers. They both sing in Bad. Santana also appears to be upset about Blaine's eye surgery and goes to Dalton Academy because she wants to find out what Sebastian put in the slushie. After a duel between them, singing Smooth Criminal, he admits that he put rock salt in it.Brittany and Kurt. They also both rap in Fly/I Believe I Can Fly during Regionals.
They are seen sitting together in the bus that will get them to Chicago.
During a scene at The Lima Bean, Blaine asks Brittany how Santana is.
Blaine mentions Santana during a conversation with Brittany while they are talking about their respective lovers (Santana and Kurt).
To get Sam out of his funk, Blaine organizes a video full of support from individuals that Sam had somehow impacted and changed their lives significantly. Since Santana appears in the video, it is implied that Blaine personally reached out to her for help.
Blaine is seen enjoying Santana's Nutbush City Limits performance.
Blaine and Sam visit Rachel, Kurt, and Santana in New York. When Blaine sings Piano Man at the Spotlight Diner, Santana can be seen dancing and enjoying the performance. Before Sam and Blaine leave New York, Santana sings along with them in their rendition of Just the Way You Are.
Sang Together (In a Group Number)
|Do They Know It's Christmas?||Extraordinary Merry Christmas||Finn, Rachel, Mercedes, Artie, Brittany, Puck, Tina, and Kurt|
|Bad||Michael||Artie and Sebastian|
|Fly/I Believe I Can Fly||On My Way||Rachel, Finn, Mercedes, and Artie|
|Paradise by the Dashboard Light||Nationals||Rachel, Finn, Mercedes, Puck, Brittany, Mike, and Kurt|
|The Scientist||The Break-Up||Rachel, Finn, Brittany, Kurt, Will, and Emma|
|You're the One That I Want||Glease||Rachel, Finn, Brittany, Kurt, Marley, and Ryder|
|We've Got Tonite||I Do||Finn, Rachel, Quinn, Kurt, Artie, Marley, Jake, and Betty|
|Mamma Mia||Guilty Pleasures||Rachel, Kurt, Kitty, Marley, Sam, and Unique|
|Just the Way You Are||Movin' Out||Rachel, Sam, and Kurt|
|The Fox||Puppet Master||Tina, Artie, Jake, Rachel, and Elliott|
|Hold On||Trio||Artie, Dani, Elliott, Kurt, Rachel, Sam, and Tina|
- It's Not Unusual by Tom Jones. (The Purple Piano Project)
- Last Friday Night by Katy Perry. (Pot o' Gold)
- Perfect by P!nk. (I Kissed a Girl)
- All You Need Is Love by The Beatles. (Love Love Love)
- They both are able to rap, as shown in Fly/I Believe I Can Fly. (On My Way)
- They were both slushied by Sebastian in the same episode. (Michael)
- Their respective former/current partners have kissed each other. (Brittany and Kurt)
- They are both gay.
- During the two different senior class president elections, they both have something to do with Brittany. (Santana campaigns with Brittany in I Am Unicorn and Blaine runs against Brittany in Makeover)
- They were both on the Cheerios and have both been made co-captains of the team alongside Becky in their respective senior years.
- Both of them have had some kind of relationship with Sam. Santana dated him and Blaine is his best friend and also had a crush on him.
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